Male microchimerism in healthy women and women with scleroderma: cells or circulating DNA? A quantitative answer.

@article{Lambert2002MaleMI,
  title={Male microchimerism in healthy women and women with scleroderma: cells or circulating DNA? A quantitative answer.},
  author={Nathalie C. Lambert and Y. M. Dennis Lo and Timothy Erickson and Tracy S. Tylee and Katherine Adams Guthrie and Daniel e. Furst and J. Lee Nelson},
  journal={Blood},
  year={2002},
  volume={100 8},
  pages={2845-51}
}
Male DNA, of presumed fetal origin, can be detected in the maternal circulation decades after delivery and is referred to as fetal microchimerism (FM). We previously found quantitatively greater FM in the circulation of women with the autoimmune disease scleroderma (SSc) than of healthy women. However, it is unknown whether this difference is due to intact circulating cells or free DNA released from breakdown in disease-affected tissues. To distinguish the origin of FM, we developed a real-time… CONTINUE READING
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