Male mice produced by in vitro culture have reduced fertility and transmit organomegaly and glucose intolerance to their male offspring.

@article{Calle2012MaleMP,
  title={Male mice produced by in vitro culture have reduced fertility and transmit organomegaly and glucose intolerance to their male offspring.},
  author={Alexandra Alvear Calle and Alberto Alvarado Miranda and Ra{\'u}l Fern{\'a}ndez-Gonz{\'a}lez and Eva Pericuesta and Ricardo Laguna and Alfonso Guti{\'e}rrez-Ad{\'a}n},
  journal={Biology of reproduction},
  year={2012},
  volume={87 2},
  pages={
          34
        }
}
It has been reported that suboptimal in vitro culture (IVC) of mouse embryos can affect the postnatal expression of epigenetically sensitive alleles, resulting in altered postnatal growth, organ dimensions, health, and behavior in the offspring. Although these detrimental impacts on the offspring are well described, the relative contribution of the IVC-produced fathers is unclear. In this work, we have analyzed if suboptimal IVC (achieved by altering the culture medium by the addition of FCS… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 25 CITATIONS

In vitro versus In vivo: Development-, Apoptosis-, and Implantation- Related Gene Expression in Mouse Blastocyst

Forough Mahdavinezhad, Parinaz Kazemi, +5 authors Mojtaba Dashtizad
  • Iranian journal of biotechnology
  • 2019
VIEW 1 EXCERPT
CITES BACKGROUND

Intergenerational transmission of paternal trauma among US Civil War ex-POWs

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND

Periconception in Physiology and Medicine

  • Advances in Experimental Medicine and Biology
  • 2017

IVF culture media: past, present and future.

  • Human reproduction update
  • 2015
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 47 REFERENCES

Effect of flanking matrix attachment regions on the expression of microinjected transgenes during preimplantation development of mouse embryos

A Gutierrez-Adan, B. Pintado
  • Transgenic Res
  • 2000
VIEW 2 EXCERPTS
HIGHLY INFLUENTIAL