Male mice deficient in microsomal epoxide hydrolase are not susceptible to benzene-induced toxicity.

@article{Bauer2003MaleMD,
  title={Male mice deficient in microsomal epoxide hydrolase are not susceptible to benzene-induced toxicity.},
  author={Alison K Bauer and Brenda Faiola and Diane J Abernethy and Rosemarie Marchan and Linda J. Pluta and Victoria A Wong and Frank J. Gonzalez and Byron E. Butterworth and Susan J. Borghoff and Jeffrey I Everitt and Leslie Recio},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2003},
  volume={72 2},
  pages={201-9}
}
Enzymes involved in benzene metabolism are likely genetic determinants of benzene-induced toxicity. Polymorphisms in human microsomal epoxide hydrolase (mEH) are associated with an increased risk of developing leukemia, specifically those associated with benzene. This study was designed to investigate the importance of mEH in benzene-induced toxicity. Male and female mEH-deficient (mEH-/-) mice and background mice (129/Sv) were exposed to inhaled benzene (0, 10, 50, or 100 ppm) 5 days/week, 6 h… CONTINUE READING
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