Male mediated caffeine effects over two generations of rats.

@article{Pollard1988MaleMC,
  title={Male mediated caffeine effects over two generations of rats.},
  author={Irina Pollard and J Smallshaw},
  journal={Journal of developmental physiology},
  year={1988},
  volume={10 3},
  pages={271-81}
}
Caffeine exposure of a male rat prior to mating affected his progeny and the progeny of a second generation. The dose chosen, 30 mg/kg per day given orally, was approximately equivalent to a caffeine intake of 10-12 cups of brewed coffee daily. In the first (F1) generation caffeine consumption of the sires for a minimum period of 15 days prior to mating with drug naive females, caused significant fetal growth retardation of both sexes and an increased postnatal mortality of pups between weeks 1… CONTINUE READING