Male hypogonadism

@article{Basaria2014MaleH,
  title={Male hypogonadism},
  author={S. Basaria},
  journal={The Lancet},
  year={2014},
  volume={383},
  pages={1250-1263}
}
Male hypogonadism is a clinical syndrome that results from failure to produce physiological concentrations of testosterone, normal amounts of sperm, or both. Hypogonadism may arise from testicular disease (primary hypogonadism) or dysfunction of the hypothalamic-pituitary unit (secondary hypogonadism). Clinical presentations vary dependent on the time of onset of androgen deficiency, whether the defect is in testosterone production or spermatogenesis, associated genetic factors, or history of… Expand
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References

SHOWING 1-10 OF 110 REFERENCES
Adult-onset idiopathic hypogonadotropic hypogonadism--a treatable form of male infertility.
TLDR
The recognition of adult-onset hypogonadotropic hypog ongonadism in men as a distinct disorder expands the spectrum of GnRH deficiency and identifies a treatable form of male infertility. Expand
Hypogonadotropic hypogonadism in hemochromatosis: recovery of reproductive function after iron depletion.
TLDR
It is concluded that phlebotomy alone may be adequate treatment for hypogonadotropic hypogOnadism in men with hemochromatosis. Expand
Klinefelter syndrome.
TLDR
Introduction of testicular sperm extraction in combination with intracytoplasmic sperm injection (ICSI) techniques has allowed non-mosaic KS males to father children. Expand
Clinical review: Why is androgen replacement in males controversial?
TLDR
It is thought that published clinical experience justifies testosterone replacement therapy in males who have not initiated puberty by age 14 and in males with low testosterone levels due to classical diseases of the hypothalamic-pituitary-gonadal axis. Expand
Osteoporosis in Men with Idiopathic Hypogonadotropic Hypogonadism
TLDR
Bone density was determined in 23 hypogonadal men with isolated gonadotropin-releasing hormone deficiency and osteopenia was equally severe in men with immature and mature bone ages, suggesting that abnormal bone development plays an important role in the osteopenia of men with idiopathic hypog onadotropic hypogOnadism. Expand
Transient hypogonadotropic hypogonadism caused by critical illness.
TLDR
It is concluded that both men and women who are critically ill uniformly develop temporary hypogonadotropic gonadal insufficiency regardless of their illness, manifested by low testosterone levels, while a comparable decrease in estradiol is present in women. Expand
Androgen receptor defects : Historical, clinical, and molecular perspectives
TLDR
AIS is an archetypal example of a hormone resistance disorder; however, due to defective androgen receptor (AR1) function, there is loss of target organ response to the hormone, and the effects of androgens are reduced or absent. Expand
Prevalence of hypothalamic-pituitary imaging abnormalities in impotent men with secondary hypogonadism.
TLDR
The risk of hypothalamic or pituitary imaging abnormalities is low among men evaluated for erectile dysfunction and secondary hypogonadism, however, this risk increases markedly when the serum testosterone level is markedly decreased. Expand
Frequent occurrence of hypogonadotropic hypogonadism in type 2 diabetes.
TLDR
It is concluded that hypog onadotropic hypogonadism occurs commonly in type 2 diabetes and correlated strongly with cFT but not with SHBG. Expand
Prolactin-screening tumors and hypogonadism in 22 men.
TLDR
The results indicate that hyperprolactinemia frequently induces hypogonadism in men, that bromocryptine ameliorates symptoms of disease previously unchanged by operation or radiotherapy, and that the impotence observed may not be solely the result of hypog onadism. Expand
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