Male germ cell-associated kinase, a male-specific kinase regulated by androgen, is a coactivator of androgen receptor in prostate cancer cells.

@article{Ma2006MaleGC,
  title={Male germ cell-associated kinase, a male-specific kinase regulated by androgen, is a coactivator of androgen receptor in prostate cancer cells.},
  author={A Ma and Liang Xia and Sonal J. Desai and David L. Boucher and Yi Guan and Hsiu-ming Shih and X B Shi and Ralph W. deVere White and Hong-wu Chen and Cliff G Tepper and Hsing-Jien Kung},
  journal={Cancer research},
  year={2006},
  volume={66 17},
  pages={8439-47}
}
Androgen receptor (AR) is a ligand-induced transcriptional factor, which plays an important role in the normal development of prostate as well as in the progression of prostate cancer. Numerous coactivators, which associate with AR and function to remodel chromatin and recruit RNA polymerase II to enhance the transcriptional potential of AR, have been identified. Among these coactivators, few are protein kinases. In this study, we describe the characterization of a novel protein kinase, male… CONTINUE READING
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cancer cells

  • L Wodicka, H Dong, M Mittmann, MH Ho, DJ Lockhart
  • 2005

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