Male fertility is linked to the selenoprotein phospholipid hydroperoxide glutathione peroxidase.

  title={Male fertility is linked to the selenoprotein phospholipid hydroperoxide glutathione peroxidase.},
  author={C Foresta and Leopold Floh{\'e} and Andrea Garolla and Antonella Roveri and Fulvio Ursini and Matilde Maiorino},
  journal={Biology of reproduction},
  volume={67 3},
The selenoprotein phospholipid hydroperoxide glutathione peroxidase (PHGPx) accounts for almost the entire selenium content of mammalian testis. PHGPx is abundantly expressed in spermatids as active peroxidase but is transformed to an oxidatively inactivated protein in mature sperm, where it is a major constituent of the mitochondrial capsule in the midpiece. Male infertility in selenium-deficient animals, which is characterized by impaired sperm motility and morphological midpiece alterations… CONTINUE READING


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