Male contraceptive Adjudin is a potential anti-cancer drug.


Adjudin, also known as AF-2364 and an analog of lonidamine (LND), is a male contraceptive acting through the induction of premature sperm depletion from the seminiferous epithelium when orally administered to adult rats, rabbits or dogs. It is also known that LND can target mitochondria and block energy metabolism in tumor cells. However, whether Adjudin… (More)
DOI: 10.1016/j.bcp.2012.11.008