Male and Female Hypogonadism.

@article{RichardEaglin2018MaleAF,
  title={Male and Female Hypogonadism.},
  author={Angela Richard-Eaglin},
  journal={The Nursing clinics of North America},
  year={2018},
  volume={53 3},
  pages={
          395-405
        }
}
Male hypogonadotropic hypogonadism in various genetic disorders
TLDR
Most of the inborn diseases that involve hypogonadotropic hypogOnadism as one of their components are reviewed to review.
Hypogonadism in Adult Males with Prader-Willi Syndrome—Clinical Recommendations Based on a Dutch Cohort Study, Review of the Literature and an International Expert Panel Discussion
TLDR
A practical algorithm for TRT in adult males with PWS is provided in order to prevent undertreatment and related adverse health outcomes and an international expert panel discussion is presented.
Hypogonadism and liver fibrosis in HIV-infected patients
TLDR
Whereas obesity is related to secondary hypogonadism, high SHBG levels, related to liver fibrosis degree and HCV co-infection, are responsible for compensated forms.
Hypogonadism in Women with Prader-Willi Syndrome—Clinical Recommendations Based on a Dutch Cohort Study, Review of the Literature and an International Expert Panel Discussion
TLDR
It is shown that hypogonadism is frequent in females with PWS, but is often undiagnosed and untreated, and practical recommendations for the screening and treatment of hypog onadism in femaleswith PWS are provided.
Mechanisms of Central Hypogonadism
TLDR
Patients with Central Hypogonadism (CH) are often vulnerable, and their clinical management requires both sensitivity and empathy.
Hypogonadotropic Hypogonadism and Juvenile Idiopathic Arthritis in an African Boy: What is the Pathophysiological Link?
TLDR
An untreated case of systemic juvenile idiopathic arthritis in a young African male with co-presentation of hypogonadotropic hypogOnadism is reported and a therapy combining corticosteroid, methotrexate for arthritis, and hormone replacement with testosterone led to regression of arthritis, biological inflammatory syndrome, and hypog onadism.
Hyperprolactinemia and Hypopituitarism in Acromegaly and Effect of Pituitary Surgery: Long-Term Follow-up on 529 Patients
TLDR
Age, sex, body mass index, tumor size, invasiveness, prolactin staining, ki-67 index, and GH/IGF-1 levels were significantly correlated with preoperative hypopituitarism and hyperprolactinemia.
Review Mechanisms of Central Hypogonadism
  • Biology, Medicine
  • 2021
TLDR
The HPG axis is susceptible to congenital malformations, with reports of mutations within >50 genes that manifest with congenital CH, including Kallmann Syndrome associated with hyposmia or anosmia (reduc‐ tion or loss of the sense of smell due to the closely associated migration of GnRH with olfactory neurons during embryogenesis).
Educational status, testosterone replacement, and intelligence outcomes in Klinefelter syndrome
TLDR
The level of education and hormonal therapy can be selectively implicated in the intellectual variability in KS, with significant differences between adult's and children's IQ and between verbal and nonverbal indexes.
A report of congenital adrenal hyperplasia due to 17α-hydroxylase deficiency in two 46,XX sisters
TLDR
A homozygous missense mutation in the CYP17A1 gene causing 17OHD in two sisters from Loja, Ecuador is reported, the first time such deficiency and mutation are described in two members of the same family in Ecuador.
...
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Male hypogonadism
Subclinical male hypogonadism.
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TLDR
The precise and early diagnosis of HH can prevent negative physical and psychological sequelae, preserve normal peak bone mass, and restore the fertility in affected patients.
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Beyond hormone replacement: quality of life in women with congenital hypogonadotropic hypogonadism
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The presumable availability of treatment does not necessarily ensure adequate quality of life for women with isolated GnRH deficiency, and women identified isolation, need for information and finding expert care as challenges to living with CHH.
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The guidelines for the evaluation and treatment of androgen deficiency syndromes in adult men published previously in 2006 are updated and testosterone therapy is recommended for men with symptomatic androgens deficiency to induce and maintain secondary sex characteristics.
Long-Term Testosterone Therapy Improves Cardiometabolic Function and Reduces Risk of Cardiovascular Disease in Men with Hypogonadism
TLDR
Long-term TU was well tolerated with excellent adherence suggesting a high level of patient satisfaction, and Mortality related to CV disease was significantly reduced in the T-group.
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