Male-Specific Fruitless Isoforms Target Neurodevelopmental Genes to Specify a Sexually Dimorphic Nervous System

@inproceedings{Neville2014MaleSpecificFI,
  title={Male-Specific Fruitless Isoforms Target Neurodevelopmental Genes to Specify a Sexually Dimorphic Nervous System},
  author={Megan C. Neville and Tetsuya Nojima and Elizabeth M C Ashley and Darren James Parker and John Walker and Tony D Southall and Bram Van de Sande and Ana Claudia Marques and Bettina Fischer and Andrea H. Brand and Steven Russell and Michael G. Ritchie and Stein Aerts and Stephen F Goodwin},
  booktitle={Current Biology},
  year={2014}
}
BACKGROUND In Drosophila, male courtship behavior is regulated in large part by the gene fruitless (fru). fru encodes a set of putative transcription factors that promote male sexual behavior by controlling the development of sexually dimorphic neuronal circuitry. Little is known about how Fru proteins function at the level of transcriptional regulation or the role that isoform diversity plays in the formation of a male-specific nervous system. RESULTS To characterize the roles of sex… CONTINUE READING
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