Malathion-induced testicular toxicity is associated with spermatogenic apoptosis and alterations in testicular enzymes and hormone levels in male Wistar rats.

@article{Geng2015MalathioninducedTT,
  title={Malathion-induced testicular toxicity is associated with spermatogenic apoptosis and alterations in testicular enzymes and hormone levels in male Wistar rats.},
  author={Xiao Ping Geng and Hua Shao and Zhihu Zhang and Jack Chakmeng Ng and Cheng Peng},
  journal={Environmental toxicology and pharmacology},
  year={2015},
  volume={39 2},
  pages={659-67}
}
Malathion has a broad range of toxicities while its reproductive effects have not been fully elucidated. In this study, we treated animals with malathion by gavage at doses of 0, 33.75, 54, and 108 mg/kg for 60 days and evaluated the alterations in histology, biochemistry and serology. Malathion caused the reduction in the sperm counts and motility. The reduced body and testis weights were coupled with mild to severe degenerative changes in seminiferous tubules. We found malathion at 54 mg/kg… CONTINUE READING
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