Malathion/oxon and lead acetate increase gene expression and protein levels of transient receptor potential canonical channel subunits TRPC1 and TRPC4 in rat endothelial cells of the blood-brain barrier.

@article{Balbuena2012MalathionoxonAL,
  title={Malathion/oxon and lead acetate increase gene expression and protein levels of transient receptor potential canonical channel subunits TRPC1 and TRPC4 in rat endothelial cells of the blood-brain barrier.},
  author={Pergentino Balbuena and Wen Li and Beverly A. Rzigalinski and Marion F Ehrich},
  journal={International journal of toxicology},
  year={2012},
  volume={31 3},
  pages={238-49}
}
This study examined the effects of malathion and lead on transient receptor potential canonical channel TRPC1/TRPC4 channels in rat brain endothelial cells as a mechanism to explain previously noted blood-brain barrier (BBB) permeability induced by these compounds. Lead, malathion, malaoxon and combinations of these were assessed for protein levels and gene… CONTINUE READING