• DOI:10.1371/journal.pone.0058345
Corpus ID: 15211279

Malate and Fumarate Extend Lifespan in Caenorhabditis elegans

@article{Edwards2013MalateAF,
  title={Malate and Fumarate Extend Lifespan in Caenorhabditis elegans},
  author={Clare B. Edwards and Neil Copes and Andres G. Brito and J. Canfield and P. Bradshaw},
  journal={PLoS ONE},
  year={2013},
  volume={8}
}

Clare B. Edwards, Neil Copes, +2 authors P. Bradshaw

Published 2013

Biology, Medicine

PLoS ONE

Malate, the tricarboxylic acid (TCA) cycle metabolite, increased lifespan and thermotolerance in the nematode C. elegans. Malate can be synthesized from fumarate by the enzyme fumarase and further oxidized to oxaloacetate by malate dehydrogenase with the accompanying reduction of NAD. Addition of fumarate also extended lifespan, but succinate addition did not, although all three intermediates activated nuclear translocation of the cytoprotective DAF-16/FOXO transcription factor and protected… CONTINUE READING

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