Malate and Fumarate Extend Lifespan in Caenorhabditis elegans

  title={Malate and Fumarate Extend Lifespan in Caenorhabditis elegans},
  author={Clare B. Edwards and Neil Copes and Andres G. Brito and J. Canfield and P. Bradshaw},
  journal={PLoS ONE},
  • Clare B. Edwards, Neil Copes, +2 authors P. Bradshaw
  • Published 2013
  • Biology, Medicine
  • PLoS ONE
  • Malate, the tricarboxylic acid (TCA) cycle metabolite, increased lifespan and thermotolerance in the nematode C. elegans. Malate can be synthesized from fumarate by the enzyme fumarase and further oxidized to oxaloacetate by malate dehydrogenase with the accompanying reduction of NAD. Addition of fumarate also extended lifespan, but succinate addition did not, although all three intermediates activated nuclear translocation of the cytoprotective DAF-16/FOXO transcription factor and protected… CONTINUE READING
    59 Citations

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