Malarone (atovaquone and proguanil hydrochloride): a review of its clinical development for treatment of malaria. Malarone Clinical Trials Study Group.

@article{Looareesuwan1999MalaroneA,
  title={Malarone (atovaquone and proguanil hydrochloride): a review of its clinical development for treatment of malaria. Malarone Clinical Trials Study Group.},
  author={Sornchai Looareesuwan and JeffreyD. Chulay and Craig J. Canfield and David B. Hutchinson},
  journal={The American journal of tropical medicine and hygiene},
  year={1999},
  volume={60 4},
  pages={
          533-41
        }
}
The continuing spread of drug-resistant malaria emphasizes the need for new antimalarial drugs. Atovaquone is a broad-spectrum antiprotozoal drug with a novel mechanism of action, via inhibition of parasite mitochondrial electron transport, and a favorable safety profile. Early studies with atovaquone alone for treatment of malaria demonstrated good initial control of parasitemia but an unacceptable rate of recrudescent parasitemia. Parasites isolated during recrudescence after treatment with… CONTINUE READING
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