Malarial parasites induce TNF production by macrophages.

@article{Bate1988MalarialPI,
  title={Malarial parasites induce TNF production by macrophages.},
  author={Colin Bate and Janice Taverne and J. H. L. Playfair},
  journal={Immunology},
  year={1988},
  volume={64 2},
  pages={227-31}
}
Mouse peritoneal macrophages incubated with erythrocytes infected with non-lethal or lethal variants of Plasmodium yoelii or with P. berghei, in the presence of polymyxin B to exclude the effects of any contaminating endotoxin, secreted a cytotoxic factor into the supernatant that was shown to be tumour necrosis factor (TNF). No differences were observed in the ability of the three types of parasite to induce TNF production, which was maximal in the range of 0.2-5 infected erythrocytes per… CONTINUE READING

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