Malarial Pigment Hemozoin and the Innate Inflammatory Response

  title={Malarial Pigment Hemozoin and the Innate Inflammatory Response},
  author={Martin S. Olivier and Kristin M. Van Den Ham and Marina Tiemi Shio and Fikregabrail Aberra Kassa and Sophie Fougeray},
  booktitle={Front. Immunol.},
Malaria is a deadly infectious disease caused by the intraerythrocytic protozoan parasite Plasmodium. The four species of Plasmodium known to affect humans all produce an inorganic crystal called hemozoin (HZ) during the heme detoxification process. HZ is released from the food vacuole into circulation during erythrocyte lysis, while the released parasites further infect additional naive red blood cells. Once in circulation, HZ is rapidly taken up by circulating monocytes and tissue macrophages… CONTINUE READING