Malaria transmission after artemether-lumefantrine and dihydroartemisinin-piperaquine: a randomized trial.

  title={Malaria transmission after artemether-lumefantrine and dihydroartemisinin-piperaquine: a randomized trial.},
  author={Patrick Sawa and Seif Abdallah Shekalaghe and Christopher J. Drakeley and Colin J. Sutherland and Collins K. Mweresa and Amrish Y. Baidjoe and Alphaxard Manjurano and Reginald A. Kavishe and Khalid B Beshir and Rahma U Yussuf and Sabah Ahmed Omar and Cornelus Hermsen and Lucy C Okell and Henk D. H. F. Schallig and Robert W. Sauerwein and Rachel L. Hallett and Teun Bousema},
  journal={The Journal of infectious diseases},
  volume={207 11},
BACKGROUND Artemisinin-based combination therapy (ACT) reduces the potential for malaria transmission, compared with non-ACTs. It is unclear whether this effect differs between ACTs. METHODS A total of 298 children (age, 6 months to 10 years) with uncomplicated falciparum malaria were randomized to artemether-lumefantrine (AL; n = 153) or dihydroartemisinin-piperaquine (DP; n = 145) in Mbita, a community in western Kenya. Gametocyte carriage was determined by molecular methods on days 0, 1, 2… CONTINUE READING
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