Malaria sporozoites leave behind trails of circumsporozoite protein during gliding motility.

@article{Stewart1988MalariaSL,
  title={Malaria sporozoites leave behind trails of circumsporozoite protein during gliding motility.},
  author={Mark J. Stewart and Jerome P. Vanderberg},
  journal={The Journal of protozoology},
  year={1988},
  volume={35 3},
  pages={389-93}
}
As Plasmodium sporozoites undergo gliding motility in vitro, they leave behind trails of circumsporozoite (CS) protein that correspond to their patterns of movement. This light microscopic observation was made using Plasmodium berghei sporozoites, a monoclonal antibody (MAb H4) directed against the immunodominant repetitive epitope of the CS protein of P. berghei, and an immunogold-silver staining (IGSS) technique. Sporozoites pretreated with agents that inhibit sporozoite motility and… CONTINUE READING

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