Malaria-specific antibody responses and parasite persistence after infection of mice with Plasmodium chabaudi chabaudi.

@article{Achtman2007MalariaspecificAR,
  title={Malaria-specific antibody responses and parasite persistence after infection of mice with Plasmodium chabaudi chabaudi.},
  author={Ariel H. Achtman and Robin Stephens and Emma Tamsin Cadman and Vicky Harrison and Jean Langhorne},
  journal={Parasite immunology},
  year={2007},
  volume={29 9},
  pages={435-44}
}
While it is known that antibodies are critical for clearance of malaria infections, it is not clear whether adequate antibody responses are maintained and what effect chronic infection has on this response. Here we show that mice with low-grade chronic primary infections of Plasmodium chabaudi or infections very recently eliminated have reduced second infections when compared with the second infection of parasite-free mice. We also show that parasite-specific antibody responses induced by… CONTINUE READING