Malaria primes the innate immune response due to interferon-gamma induced enhancement of toll-like receptor expression and function.

@article{Franklin2009MalariaPT,
  title={Malaria primes the innate immune response due to interferon-gamma induced enhancement of toll-like receptor expression and function.},
  author={Bernardo S Franklin and Peggy Parroche and Marco Ant{\^o}nio Ata{\'i}de and Fanny N. Lauw and Catherine Ropert and Rosane Barbosa de Oliveira and Dhelio Batista Pereira and Mauro Shugiro Tada and Paulo Nogueira and Luiz Hildebrando Pereira da Silva and Harry Bjorkbacka and Douglas T Golenbock and Ricardo Tostes Gazzinelli},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 14},
  pages={5789-94}
}
Malaria-induced sepsis is associated with an intense proinflammatory cytokinemia for which the underlying mechanisms are poorly understood. It has been demonstrated that experimental infection of humans with Plasmodium falciparum primes Toll-like receptor (TLR)-mediated proinflammatory responses. Nevertheless, the relevance of this phenomenon during natural infection and, more importantly, the mechanisms by which malaria mediates TLR hyperresponsiveness are unclear. Here we show that TLR… CONTINUE READING