Malaria prevention: from immunological concepts to effective vaccines and protective antibodies

@article{Cockburn2018MalariaPF,
  title={Malaria prevention: from immunological concepts to effective vaccines and protective antibodies},
  author={Ian A. Cockburn and Robert A Seder},
  journal={Nature Immunology},
  year={2018},
  volume={19},
  pages={1199-1211}
}
Development of a malaria vaccine remains a critical priority to decrease clinical disease and mortality and facilitate eradication. Accordingly, RTS,S, a protein-subunit vaccine, has completed phase III clinical trials and confers ~30% protection against clinical infection over 4 years. Whole-attenuated-sporozoite and viral-subunit vaccines induce between 20% and 100% protection against controlled human malaria infection, but there is limited published evidence to date for durable, high-level… CONTINUE READING
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