Malaria parasites tolerate a broad range of ionic environments and do not require host cation remodelling.

@article{Pillai2013MalariaPT,
  title={Malaria parasites tolerate a broad range of ionic environments and do not require host cation remodelling.},
  author={Ajay Pillai and Rachel Addo and Paresh Sharma and Wang Nguitragool and Prakash Srinivasan and Sanjay A Desai},
  journal={Molecular microbiology},
  year={2013},
  volume={88 1},
  pages={
          20-34
        }
}
Malaria parasites grow within erythrocytes, but are also free in host plasma between cycles of asexual replication. As a result, the parasite is exposed to fluctuating levels of Na(+) and K(+) , ions assumed to serve important roles for the human pathogen, Plasmodium falciparum. We examined these assumptions and the parasite's ionic requirements by establishing continuous culture in novel sucrose-based media. With sucrose as the primary osmoticant and K(+) and Cl(-) as the main extracellular… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 16 CITATIONS

Ion Regulation in the Malaria Parasite.

  • Annual review of microbiology
  • 2015
VIEW 6 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

The malaria parasite cation ATPase PfATP4 and its role in the mechanism of action of a new arsenal of antimalarial drugs

  • International journal for parasitology. Drugs and drug resistance
  • 2015
VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 64 REFERENCES

Perturbation of the pump-leak balance for Na(+) and K(+) in malaria-infected erythrocytes.

  • American journal of physiology. Cell physiology
  • 2001
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Dependence of Plasmodium falciparum in vitro growth on the cation permeability of the human host erythrocyte.

  • Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
  • 2003
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Similar Papers

Loading similar papers…