Malaria parasites co-opt human factor H to prevent complement-mediated lysis in the mosquito midgut.

@article{Simon2013MalariaPC,
  title={Malaria parasites co-opt human factor H to prevent complement-mediated lysis in the mosquito midgut.},
  author={Nina S. C. Simon and Edwin Lasonder and Matthias Scheuermayer and Andrea A. K{\"u}hn and Sabrina Tews and Rainer Fischer and Peter F Zipfel and Christine Skerka and Gabriele Pradel},
  journal={Cell host & microbe},
  year={2013},
  volume={13 1},
  pages={29-41}
}
Human complement is a first line defense against infection in which circulating proteins initiate an enzyme cascade on the microbial surface that leads to phagocytosis and lysis. Various pathogens evade complement recognition by binding to regulator proteins that protect host cells from complement activation. We show that emerging gametes of the malaria parasite Plasmodium falciparum bind the host complement regulator factor H (FH) following transmission to the mosquito to protect from… CONTINUE READING
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