Malaria parasites can develop stable resistance to artemisinin but lack mutations in candidate genes atp6 (encoding the sarcoplasmic and endoplasmic reticulum Ca2+ ATPase), tctp, mdr1, and cg10.

@article{Afonso2006MalariaPC,
  title={Malaria parasites can develop stable resistance to artemisinin but lack mutations in candidate genes atp6 (encoding the sarcoplasmic and endoplasmic reticulum Ca2+ ATPase), tctp, mdr1, and cg10.},
  author={Ana Afonso and P Hunt and S Cheesman and Ana Cristina Alves and C V Cunha and Virg{\'i}lio E. do Ros{\'a}rio and Pedro Manuel Mendonça Silva Cravo},
  journal={Antimicrobial agents and chemotherapy},
  year={2006},
  volume={50 2},
  pages={
          480-9
        }
}
Resistance of Plasmodium falciparum to drugs such as chloroquine and sulfadoxine-pyrimethamine is a major problem in malaria control. Artemisinin (ART) derivatives, particularly in combination with other drugs, are thus increasingly used to treat malaria, reducing the probability that parasites resistant to the components will emerge. Although stable resistance to artemisinin has yet to be reported from laboratory or field studies, its emergence would be disastrous because of the lack of… CONTINUE READING

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