Malaria parasites are rapidly killed by dantrolene derivatives specific for the plasmodial surface anion channel.

@article{Kang2005MalariaPA,
  title={Malaria parasites are rapidly killed by dantrolene derivatives specific for the plasmodial surface anion channel.},
  author={Myungsa Kang and Godfrey O Lisk and Stephen Hollingworth and Stephen M Baylor and Sanjay A Desai},
  journal={Molecular pharmacology},
  year={2005},
  volume={68 1},
  pages={
          34-40
        }
}
Dantrolene was recently identified as a novel inhibitor of the plasmodial surface anion channel (PSAC), an unusual ion channel on Plasmodium falciparum-infected human red blood cells. Because dantrolene is used clinically, has a high therapeutic index, and has desirable chemical synthetic properties, it may be a lead compound for antimalarial development. However, dantrolene derivatives would need to preferentially interact with PSAC over the sarcoplasmic reticulum (SR) Ca2+ release channel to… CONTINUE READING

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