Malaria in pregnancy: linking immunity and pathogenesis to prevention.

  title={Malaria in pregnancy: linking immunity and pathogenesis to prevention.},
  author={Stephen J Rogerson and Victor Mwapasa and Steven Richard Meshnick},
  journal={The American journal of tropical medicine and hygiene},
  volume={77 6 Suppl},
Pregnant women are susceptible to malaria during pregnancy. Plasmodium falciparum, which sequesters in the placenta, causes the greatest disease, contributing significantly to maternal and infant mortality. Parasitized cells in the placenta express unique variant surface antigens (VSA), predominantly the VAR2CSA protein, and lack of immunity to these pregnancy-specific variant surface antigens explains some of the pregnancy-associated malaria susceptibility. Changes in acquired cellular… CONTINUE READING
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