Malaria-derived hemozoin exerts early modulatory effects on the phenotype and maturation of human dendritic cells.

@article{Bujila2016MalariaderivedHE,
  title={Malaria-derived hemozoin exerts early modulatory effects on the phenotype and maturation of human dendritic cells.},
  author={Ioana Bujila and Evelin Schwarzer and Oleksii A Skorokhod and Jessica M. Weidner and Marita Troye-Blomberg and Ann-Kristin {\"O}stlund Farrants},
  journal={Cellular microbiology},
  year={2016},
  volume={18 3},
  pages={413-23}
}
Plasmodium falciparum (P. falciparum)-induced effects on the phenotype of human dendritic cells (DC) could contribute to poor induction of long-lasting protective immunity against malaria. DC ability to present antigens to naïve T cells, thus initiating adaptive immune responses depends on complex switches in chemokine receptors, production of soluble mediators and expression of molecules enabling antigen-presentation and maturation. To examine the cellular basis of these processes in the… CONTINUE READING
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