Malaria Vector Control Still Matters despite Insecticide Resistance.

  title={Malaria Vector Control Still Matters despite Insecticide Resistance.},
  author={Haoues Alout and Pierrick Labb{\'e} and Fabrice Chandre and Anna Cohuet},
  journal={Trends in parasitology},
  volume={33 8},

The need for practical insecticide-resistance guidelines to effectively inform mosquito-borne disease control programs

It is concluded that additional testing guidelines are needed to determine practical resistance—the efficacy of vector control tools under relevant local conditions— in order to obtain programmatic impact.

Efficacy of vector control tools against malaria-infected mosquitoes

Within mosquito vector populations, infectious mosquitoes are the ones completing the transmission of pathogens to susceptible hosts and they are, consequently, of great epidemiological interest.

Pyrethroid Resistance in Anopheles gambiae Not Associated with Insecticide-Treated Mosquito Net Effectiveness Across Sub-Saharan Africa.

ITNs decreased the risk of malaria independent of the levels of pyrethroid resistance in malaria vector populations, and the meta-regression approach did not explain any of the variance in subnational estimates of ITN effectiveness for any ofThe outcomes.

Effects of pyrethroid exposure and insecticide resistance on the sporogonic development of Plasmodium falciparum in Anopheles gambiae s.l.

Results imply that even if resistant mosquitoes survive insecticide exposure, their vector competence is impaired as parasite development is affected, suggesting that pyrethroid-based interventions could still have a role in malaria control at least until alternative insecticides are available.

Omitting age-dependent mosquito mortality in malaria models underestimates the effectiveness of insecticide-treated nets

It is found that including age-dependent mortality greatly alters the anticipated effects of insecticides on nets on mosquito transmission potential, and that ignoring this realism potentially overestimates the negative impact of insecticide resistance.

Biological Control of Mosquito-Borne Diseases: The Potential of Wolbachia-Based Interventions in an IVM Framework

The current state of knowledge about the association between mosquitoes and Wolbachia is discussed, emphasizing the limitations of different mosquito control strategies and the use of mosquitoes' commensal microbiota as innovative approaches to control mosquito-borne diseases.

Wolbachia: A biological control strategy against arboviral diseases.

Biology of the Wolbachia and its implication as a control measure for arboviral diseases mainly Dengue and Chikungunya is focused on.

The sub-lethal effects of pyrethroid exposure on Anopheles gambiae s.l. life-history traits, behaviour, and the efficacy of insecticidal bednets

The results suggest community protection offered by first-generation LLINs is extremely low in this setting, however, pyrethroid-PBO nets appear to be effective at controlling the highly pyrethoid-resistant population.



Insecticide exposure impacts vector–parasite interactions in insecticide-resistant malaria vectors

Insecticide resistance leads to a selective pressure of insecticides on Plasmodium parasites, providing, to the authors' knowledge, the first evidence of genotype by environment interactions on vector competence in a natural Anopheles–Plas modium combination.

Insecticide Control of Vector-Borne Diseases: When Is Insecticide Resistance a Problem?

Evidence is reviewed that insecticide resistance may have an impact on the quality of vectors and, specifically, on three key determinants of parasite transmission: vector longevity, competence, and behaviour, which may lead to a dramatic increase in the transmission of the disease and to a higher prevalence than in the absence of insecticides.

Fungal infection counters insecticide resistance in African malaria mosquitoes

It is shown that insecticide-resistant Anopheles mosquitoes remain susceptible to infection with the fungus Beauveria bassiana, and fungal infection reduced the expression of resistance to the key public health insecticides permethrin and dichlorodiphenyltrichloroethane.

Interactive cost of Plasmodium infection and insecticide resistance in the malaria vector Anopheles gambiae

Evidence for a survival cost associated with infection by Plasmodium parasite only in mosquito selected for insecticide resistance is provided, which suggests that the selection of insecticides resistance mutation may have disturbed the interaction between parasites and vectors, resulting in increased cost of infection.


Determining the public health impact of physiological and behavioral insecticide resistance is an urgent priority if the authors are to maintain the significant gains made in reducing malaria morbidity and mortality.

Insecticide Resistance Alleles Affect Vector Competence of Anopheles gambiae s.s. for Plasmodium falciparum Field Isolates

Insecticide resistance, which is particularly problematic for malaria control efforts, impacts vector competence towards P. falciparum and probably parasite transmission through increased sporozoite prevalence in kdr resistant mosquitoes.

The Effects of Age, Exposure History and Malaria Infection on the Susceptibility of Anopheles Mosquitoes to Low Concentrations of Pyrethroid

The data suggest the possibility that, where high insecticide coverage can be achieved, low concentration formulations have the capacity to reduce disease transmission without the massive selection for resistance imposed by current practice.

Towards evolution-proof malaria control with insecticides

It is suggested that using alternative insecticides, or conventional insecticides in alternative ways, might enable effective control, but delay considerably or prevent the evolution of resistance.

The threat (or not) of insecticide resistance for malaria control

Malaria burdens have fallen dramatically this century, in large part because around a billion long-lasting insecticide-treated bed nets (LLINs) have been introduced into Africa (1, 2). Hanging over