Malaria Parasite cGMP-dependent Protein Kinase Regulates Blood Stage Merozoite Secretory Organelle Discharge and Egress

  title={Malaria Parasite cGMP-dependent Protein Kinase Regulates Blood Stage Merozoite Secretory Organelle Discharge and Egress},
  author={C. Collins and F. Hackett and Malcolm Strath and Maria Penzo and C. Withers-Martinez and D. Baker and M. Blackman},
  journal={PLoS Pathogens},
  • C. Collins, F. Hackett, +4 authors M. Blackman
  • Published 2013
  • Biology, Medicine
  • PLoS Pathogens
  • The malaria parasite replicates within an intraerythrocytic parasitophorous vacuole (PV). Eventually, in a tightly regulated process called egress, proteins of the PV and intracellular merozoite surface are modified by an essential parasite serine protease called PfSUB1, whilst the enclosing PV and erythrocyte membranes rupture, releasing merozoites to invade fresh erythrocytes. Inhibition of the Plasmodium falciparum cGMP-dependent protein kinase (PfPKG) prevents egress, but the underlying… CONTINUE READING
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