Malaria: targeting parasite and host cell kinomes.

  title={Malaria: targeting parasite and host cell kinomes.},
  author={Christian Doerig and Abdirahman Abdi and Nicholas S. Bland and Sylvain C P Eschenlauer and Dominique Dorin-Semblat and Clare Fennell and Jean Halbert and Zoe JM Holland and Marie-Paule Nivez and Jean-Philippe Semblat and Audrey Sicard and Luc Reininger},
  journal={Biochimica et biophysica acta},
  volume={1804 3},
Malaria still remains one of the deadliest infectious diseases, and has a tremendous morbidity and mortality impact in the developing world. The propensity of the parasites to develop drug resistance, and the relative reluctance of the pharmaceutical industry to invest massively in the developments of drugs that would offer only limited marketing prospects, are major issues in antimalarial drug discovery. Protein kinases (PKs) have become a major family of targets for drug discovery research in… CONTINUE READING
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