Maladaptive plasticity of serotonin axon terminals in levodopa-induced dyskinesia.

  title={Maladaptive plasticity of serotonin axon terminals in levodopa-induced dyskinesia.},
  author={Daniella Rylander and Martin Parent and Sean Stephen O'Sullivan and Sandra Dovero and A. J. Lees and Erwan B{\'e}zard and Laurent Descarries and M. Angela Cenci},
  journal={Annals of neurology},
  volume={68 5},
OBJECTIVE Striatal serotonin projections have been implicated in levodopa-induced dyskinesia by providing an unregulated source of dopamine release. We set out to determine whether these projections are affected by levodopa treatment in a way that would favor the occurrence of dyskinesia. METHODS As an index of terminal serotonin innervation density, we measured radioligand binding to the plasma membrane serotonin transporter (SERT) in levodopa-treated dyskinetic and nondyskinetic subjects… CONTINUE READING
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