Mal de Meleda: A Report of Four Cases from the United Arab Emirates

@article{Lestringant1997MalDM,
  title={Mal de Meleda: A Report of Four Cases from the United Arab Emirates},
  author={G G Lestringant and P. M. Frossard and Ernest Adeghate and K I Qayed},
  journal={Pediatric Dermatology},
  year={1997},
  volume={14}
}
Abstract: Mal de Meleda (MDM), or recessive transgressive palmoplantar keratoderma, is a rare disorder, MDM may have originated as a founder mutation that occurred on the island of Meleda, now Mljet, in Croatia, where it was first described. However, the condition has also been observed in countries distant from Mljet. The presentation of the disease in young patients has not been reported and the progressiveness of the lesions is debated. We examined four young United Arab Emirates nationals… Expand
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TLDR
The relationship between the patients in Meleda and those in Anatolia awaits discovery by further researches that will be carried out with the collaboration of dermatology, genetics and medical history departments. Expand
Heterozygous manifestations in female carriers of Mal de Meleda
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It is demonstrated that three different homozygous mutations (82delT, C77R, and C99Y) are responsible for MDM disease in 17 patients belonging to eight consanguineous families from Northern Tunisia and during clinical assessment of MDM families in Tunisia, some family members presented with minor clinical signs. Expand
Mal de Meleda: Genetic Haplotype Analysis and Clinicopathological Findings in Cases Originating from the Island of Mljet (Meleda), Croatia
TLDR
This review characterizes mal de Meleda in its original setting and shows that the sporadic cases found in the regions of medieval trade routes of the Republic of Dubrovnik (Middle East and Northern Africa) carry the same mutation as the patients from Mljet Island, Croatia. Expand
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TLDR
The findings suggest that the MDM gene may also have originated elsewhere than in Mljet, and 24 new cases from Turkey are added to the list in the literture. Expand
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TLDR
A focused review highlights the clinical and histological features, differential diagnoses, genetic background, and the current thoughts on management of Mal de Meleda. Expand
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TLDR
It is indicated that the MDM type of transgressive PPK is caused by SLURP-1 mutations in patients from various origins and allelic heterogeneity for mutations in SLURp-1 is demonstrated. Expand
Clinical and genetic studies of 3 large, consanguineous, Algerian families with Mal de Meleda.
TLDR
Clinical and genetic analysis of the clinical and genetic characteristics of 3 large, consanguineous, Algerian families indicated that a single gene is responsible for mal de Meleda in this population. Expand
Further evidence of the clinical and genetic heterogeneity of recessive transgressive PPK in the Mediterranean region
TLDR
A Tunisian family with three siblings presenting with recessive transgressive PPK closely resembling the MDM phenotype that excludes linkage to the ARS gene is reported. Expand
Mal de Meleda in a taiwanese.
TLDR
A 27-year-old Taiwanese woman who had a history of palmoplantar keratoderma since birth presented with severe erythrokeratoderMA of the hands and feet in a glove-and-stocking distribution with conical tapering of the fingers, and involvement of the skin over the major joints and thighs. Expand
Mal de Meleda: a report of two cases of familial occurrence.
TLDR
Clinical features are the result of abnormal palmoplantar keratinization and include severe symmetrical transgressive hyperkeratosis and erythema of the feet and hands in a glove-and-sock pattern. Expand
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Report of a family with mal de Meleda in Taiwan: a clinical, histopathological and immunological study.
TLDR
A family in Taiwan is reported to have Mal de Meleda with possibly autosomal recessive inheritance among 5 of its members, and erythema of the nose, cheeks, and the perioral area in 4 affected members, actinic elastosis in 2 severely affected members and partially impaired cell-mediated immunity in vitro in both affected and unaffected members are notable findings. Expand
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TLDR
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