Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

  title={Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction},
  author={K. Fitzgerald and E. P{\aa}lsson-McDermott and A. Bowie and C. Jefferies and A. Mansell and G. Brady and E. Brint and A. Dunne and Pearl Gray and M. Harte and D. McMurray and Dirk E. Smith and J. Sims and T. Bird and L. O’Neill},
  • K. Fitzgerald, E. Pålsson-McDermott, +12 authors L. O’Neill
  • Published 2001
  • Biology, Medicine
  • Nature
  • The recognition of microbial pathogens by the innate immune system involves Toll-like receptors (TLRs), which recognize pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns, with TLR-4 mediating the response to lipopolysaccharide from Gram-negative bacteria. All TLRs have a Toll/IL-1 receptor (TIR) domain, which is responsible for signal transduction. MyD88 is one such protein that contains a TIR domain. It acts as an adapter, being… CONTINUE READING
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