Making vitamin C lipophilic enhances its protective effect against free radical induced peroxidation of low density lipoprotein.

@article{Liu1998MakingVC,
  title={Making vitamin C lipophilic enhances its protective effect against free radical induced peroxidation of low density lipoprotein.},
  author={Zhen-ling Liu and Lan Ping Ma and Zhong Li Liu},
  journal={Chemistry and physics of lipids},
  year={1998},
  volume={95 1},
  pages={49-57}
}
The peroxidation of human low density lipoprotein (LDL) was initiated by water-soluble initiator 2,2'-azobis(2-amidinopropane hydrochloride) (AAPH) and copper and inhibited by vitamin C (VC) and its lipophillic derivatives ascorbyl-6-caprylate (VC-8), 6-laurate (VC-12) and 6-palmitate (VC-16), respectively. The peroxidation was monitored by oxygen uptake, by decay of alpha-tocopherol and by formation of lipid oxidation products. Kinetic analysis of the antioxidation process demonstrates that… CONTINUE READING
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