Making the connection - shared molecular machinery and evolutionary links underlie the formation and plasticity of occluding junctions and synapses.


The pleated septate junction (pSJ), an ancient structure for cell-cell contact in invertebrate epithelia, has protein components that are found in three more-recent junctional structures, the neuronal synapse, the paranodal region of the myelinated axon and the vertebrate epithelial tight junction. These more-recent structures appear to have evolved through… (More)
DOI: 10.1242/jcs.186627


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