Corpus ID: 86062750

Making the Good Much Better Against Cancer Synthesis, Anti-tubulin and Antiproliferative Structure-Activity Relationship of Steroidomimetic Dihydroisoquinolinones

@inproceedings{Michael2014MakingTG,
  title={Making the Good Much Better Against Cancer Synthesis, Anti-tubulin and Antiproliferative Structure-Activity Relationship of Steroidomimetic Dihydroisoquinolinones},
  author={S. Michael and A. Mannheim and Jon M. Walmsley},
  year={2014}
}
  • S. Michael, A. Mannheim, Jon M. Walmsley
  • Published 2014
  • Biology
  • Tubulin, the building-block protein of cellular microtubules, is a well-validated cancer drug target: Disrupting tubulin polymerization affects cytoskeletal function and thus cell division. The vinca alkaloids, taxanes, and other taxane site binders have found wide therapeutic application and constitute one of the most successful classes of anticancer agent. Nevertheless, current drugs that target tubulin still suffer from limited therapeutic window, acquired resistance, lack of oral… CONTINUE READING