Making the First Anti-Depressant: Amphetamine in American Medicine, 1929-1950

@article{Rasmussen2006MakingTF,
  title={Making the First Anti-Depressant: Amphetamine in American Medicine, 1929-1950},
  author={Nicolas Rasmussen},
  journal={Journal of the History of Medicine and Allied Sciences},
  year={2006},
  volume={61},
  pages={288 - 323}
}
  • N. Rasmussen
  • Published 19 June 2006
  • Medicine
  • Journal of the History of Medicine and Allied Sciences
E are accustomed to thinking of the widespread use of anti-depressant drugs as a recent phenomenon, and one of decidedly mixed blessings. While no doubt effective, their phenomenal popularity since the 1990s has raised questions about the medicalization of problems of living and the fading boundaries between healing and medical enhancement (or the specter of “cosmetic pharmacology,” in Peter Kramer’s pithy formulation). Today’s anti-depressants have also, for some critics, come to symbolize the… 
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References

SHOWING 1-10 OF 118 REFERENCES
Observations on Benzedrine
TLDR
Benzedrine has now been given to over 250 in patients, out-patients, and normal subjects at this hospital, and in a proportion of these only the subjective and objective results of administration have been noted, but in more than a hundred cases systematic experiments were carried out.
ADDICTION TO AMPHETAMINE SULFATE
TLDR
The purpose in this report is to warn against the possibility of addiction by the continued use of this new stimulating drug amphetamine in the treatment of obesity.
Prozac on the couch : prescribing gender in the era of wonder drugs
Pills replaced the couch; neuroscience took the place of talk therapy; and as psychoanalysis faded from the scene, so did the castrating mothers and hysteric spinsters of Freudian theory. Or so the
THE USE OF BENZEDRINE FOR THE TREATMENT OF NARCOLEPSY
TLDR
Pharmacologic studies indicated thatBenzedrine has a more stimulating effect on the higher centers of the central nervous system than ephedrine, as manifested by its ability to awaken experimental animals from intraperitoneal barbital anesthesia and by its insomnia-producing effect in human beings.
COLLAPSE WITH DEATH FOLLOWING THE USE OF AMPHETAMINE SULFATE
TLDR
During the past few years the use of amphetamine sulfate as a stimulating drug has become increasingly widespread, and the public is becoming familiar with it, and its use among students is probably more common than one would think.
THE STIMULATING ACTION OF BENZEDRINE SULFATE: A COMPARATIVE STUDY OF THE RESPONSES OF NORMAL PERSONS AND OF DEPRESSED PATIENTS
TLDR
Benzedrine was given prominence as an astringent to the human nasal mucosa, chiefly through the work of Bertolet, Byrne, 8 Scarano 9 and Wood.
CLINICAL OBSERVATIONS ON THE EFFECT OF BENZEDRINE SULFATE: A STUDY OF PATIENTS WITH STATES OF CHRONIC EXHAUSTION, DEPRESSION AND PSYCHONEUROSIS
TLDR
Benzedrine has been utilized particularly in the treatment of congestion of the nasal mucosa, in maintaining blood pressure during spinal anesthesia and in orthostatic hypotension, and for the relief of spasm affecting the gastro-intestinal tract.
Mental ills and bodily cures : psychiatric treatment in the first half of the twenthieth century
"Mental Ills and Bodily Cures" depicts a time when psychiatric medicine went to lengths we now find extreme and perhaps even brutal ways to heal the mind by treating the body. From a treasure trove
FURTHER OBSERVATIONS ON BENZEDRINE
".anxiety states," three schizophrenics, and one organic (manic-depressive with disseminated sclerosis). At the beginning of this study the pressor effect of the drug was studied as well as its
The action and clinical use of ephedrine, an alkaloid isolated from the Chinese drug ma huang; historical document.
TLDR
Ma huang (Ephedra vulgarisvar) has been known in Chinese medicine for some 5,100 years and was one of the drugs tasted by Emperor Shen Nung, and has been incorporated into many famous prescriptions, including one for typhoid.
...
1
2
3
4
5
...