Making sense of the COP9 signalosome. A regulatory protein complex conserved from Arabidopsis to human.

@article{Wei1999MakingSO,
  title={Making sense of the COP9 signalosome. A regulatory protein complex conserved from Arabidopsis to human.},
  author={Ning Wei and Xing Wang Deng},
  journal={Trends in genetics : TIG},
  year={1999},
  volume={15 3},
  pages={
          98-103
        }
}
The COP9 signalosome, once defined as a repressor complex of light-activated development in Arabidopsis, has recently been found in humans and is probably present in most multicellular organisms. The COP9 signalosome is closely related to the lid sub-complex of the 26S proteasome in structural composition and probably shares a common evolutionary ancestor. A multifaceted role of the COP9 signalosome in cell-signaling processes is hinted at by its associated novel kinase activity, as well as the… CONTINUE READING

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