Making recombinant proteins in filamentous fungi- are we expecting too much?

@inproceedings{Nevalainen2014MakingRP,
  title={Making recombinant proteins in filamentous fungi- are we expecting too much?},
  author={Helena Nevalainen and Robyn Peterson},
  booktitle={Front. Microbiol.},
  year={2014}
}
Hosts used for the production of recombinant proteins are typically high-protein secreting mutant strains that have been selected for a specific purpose, such as efficient production of cellulose-degrading enzymes. Somewhat surprisingly, sequencing of the genomes of a series of mutant strains of the cellulolytic Trichoderma reesei, widely used as an expression host for recombinant gene products, has shed very little light on the nature of changes that boost high-level protein secretion. While… CONTINUE READING
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