Making proteins in the powerhouse.

  title={Making proteins in the powerhouse.},
  author={B. Martin H{\"a}llberg and Nils-G{\"o}ran Larsson},
  journal={Cell metabolism},
  volume={20 2},
Understanding regulation of mitochondrial DNA (mtDNA) expression is of considerable interest given that mitochondrial dysfunction is important in human pathology and aging. Similar to the situation in bacteria, there is no compartmentalization between transcription and translation in mitochondria; hence, both processes are likely to have a direct molecular crosstalk. Accumulating evidence suggests that there are important mechanisms for regulation of mammalian mtDNA expression at the… CONTINUE READING
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