Making insulin-deficient type 1 diabetic rodents thrive without insulin.

  title={Making insulin-deficient type 1 diabetic rodents thrive without insulin.},
  author={Xinxin Yu and Byung-Hyun Park and May-yun Wang and Zhao V Wang and Roger H. Unger},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={105 37},
Terminally ill insulin-deficient rodents with uncontrolled diabetes due to autoimmune or chemical destruction of beta-cells were made hyperleptinemic by adenoviral transfer of the leptin gene. Within approximately 10 days their severe hyperglycemia and ketosis were corrected. Despite the lack of insulin, moribund animals resumed linear growth and appeared normal. Normoglycemia persisted 10-80 days without other treatment; normal physiological conditions lasted for approximately 175 days despite… CONTINUE READING
Highly Influential
This paper has highly influenced 18 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 98 extracted citations


Publications referenced by this paper.
Showing 1-10 of 28 references

Similar Papers

Loading similar papers…