Making connections: insulators organize eukaryotic chromosomes into independent cis-regulatory networks.

@article{Chetverina2014MakingCI,
  title={Making connections: insulators organize eukaryotic chromosomes into independent cis-regulatory networks.},
  author={Darya Chetverina and Tsutomu Aoki and Maksim Erokhin and Pavel Georgiev and Paul Schedl},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={2014},
  volume={36 2},
  pages={163-72}
}
Insulators play a central role in subdividing the chromosome into a series of discrete topologically independent domains and in ensuring that enhancers and silencers contact their appropriate target genes. In this review we first discuss the general characteristics of insulator elements and their associated protein factors. A growing collection of insulator proteins have been identified including a family of proteins whose expression is developmentally regulated. We next consider several… CONTINUE READING

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