Making an effective switch at the kinetochore by phosphorylation and dephosphorylation

@article{Funabiki2013MakingAE,
  title={Making an effective switch at the kinetochore by phosphorylation and dephosphorylation},
  author={Hironori Funabiki and David J Wynne},
  journal={Chromosoma},
  year={2013},
  volume={122},
  pages={135-158}
}
The kinetochore, the proteinaceous structure on the mitotic centromere, functions as a mechanical latch that hooks onto microtubules to support directional movement of chromosomes. The structure also brings in a number of signaling molecules, such as kinases and phosphatases, which regulate microtubule dynamics and cell cycle progression. Erroneous microtubule attachment is destabilized by Aurora B-mediated phosphorylation of multiple microtubule-binding protein complexes at the kinetochore… CONTINUE READING