Making a tumour's bed: glioblastoma stem cells and the vascular niche

  title={Making a tumour's bed: glioblastoma stem cells and the vascular niche},
  author={Richard J. Gilbertson and Jeremy N. Rich},
  journal={Nature Reviews Cancer},
Parallel to the role that normal stem cells play in organogenesis, cancer stem cells are thought to be crucial for tumorigenesis. Understanding normal development might therefore lead to better treatments of cancer. We review recent data that stem cells of glioblastoma, a highly malignant brain tumour, seem to be dependent on cues from aberrant vascular niches that mimic the normal neural stem cell niche. These data have direct implications for cancer, highlighting the similarity between normal… 
The cancer stem cell microenvironment and anti-cancer therapy
Cancer stem cells are believed to share many properties with normal stem cells that render them relatively insensitive to classical radio- and chemotherapy, and how the interactions with the microenvironment – ‘the niche’ – control those aspects of stem cell biology is discussed.
Interaction of Brain Cancer Stem Cells and the Tumour Microenvironment: A Computational Study
A computational model is proposed that includes a heterogeneous population of cancer cells and investigates the dynamics of tumour growth as well as the eects of the tumour microenvironment.
Implications of Glioblastoma Stem Cells in Chemoresistance
An integrated view of the markers, niche, and vasculature, as well as therapeutic resistance, is essential to understand the key processes occurring within glioma stem cells and, therefore, to identify potential therapeutic targets that can lead to the development of more effective cancer treatments.
Relationship of neural stem cells with their vascular niche: Implications in the malignant progression of gliomas
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The Three-Layer Concentric Model of Glioblastoma: Cancer Stem Cells, Microenvironmental Regulation, and Therapeutic Implications
This GBM model provides explanation of the effects mediated by the tumour microenvironment on the phenotypic and molecular regulation of GBM stem cells, describing their spatial distribution in the tumor bulk.
Biology of glioma cancer stem cells
The current understanding of glioma cancer stem cell biology is reviewed, with a focus on cells that are undifferentiated, self-renewing, with the capacity for developing tumors (tumorigenic) cells.
The Stem Cell Vascular Niche in Brain Tumorigenesis
The cellular and molecular components of stem cell vascular niche are summarized with a special emphasis on brain tumors and it is conceivable that mutation at the level of vasculature may translate to an abnormal vascular niche discharging unregulated stem cell signals and thus propel aberrant cancer stem cells to achieve their lethal malignant potential.
Brain tumor stem cells: bringing order to the chaos of brain cancer.
  • P. Dirks
  • Biology
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2008
New in vitro and in vivo models for interrogating brain tumor cells in stem-cell conditions have been developed that provide important new opportunities for elucidating the key pathways responsible for driving the proliferation of these cells.


A perivascular niche for brain tumor stem cells.
Stem Cells and Cancer: Two Faces of Eve
Stem Cells and Their Niches
The stem cell niche concept is discussed, recent progress is highlighted, and important unanswered questions are identified.
Identification of human brain tumour initiating cells
The development of a xenograft assay that identified human brain tumour initiating cells that initiate tumours in vivo gives strong support for the CSC hypothesis as the basis for many solid tumours, and establishes a previously unidentified cellular target for more effective cancer therapies.
The stem-cell niche as an entity of action
The interplay between stem cells and their niche creates the dynamic system necessary for sustaining tissues, and for the ultimate design of stem-cell therapeutics.
Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells
Findings show that the BMP–BMPR signalling system—which controls the activity of normal brain stem cells—may also act as a key inhibitory regulator of tumour-initiating, stem-like cells from GBMs and identify BMP4 as a novel, non-cytotoxic therapeutic effector, which may be used to prevent growth and recurrence of GBMs in humans.
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The identification of colon cancer stem cells that are distinct from the bulk tumour cells provides strong support for the hierarchical organization of human colon cancer, and their existence suggests that for therapeutic strategies to be effective, they must target the cancer stem Cells.
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It is highlighted the possibility that selective eradication of TSLC may be achieved by targeting the tumor microenvironment (and potentially a supportive TSLC niche) rather than the TSLC directly, and a possible new mechanism to explain the ability of antiangiogenic therapy to enhance the efficacy of chemotherapy is suggested.
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Data indicate that stem cell-like tumor cells can be a crucial source of key angiogenic Factors in cancers and that targeting proangiogenic factors from stem cell -like tumor populations may be critical for patient therapy.