Making a medicine out of MDMA.
@article{Sessa2015MakingAM, title={Making a medicine out of MDMA.}, author={Ben Sessa and David J. Nutt}, journal={The British journal of psychiatry : the journal of mental science}, year={2015}, volume={206 1}, pages={ 4-6 } }
From its first use 3,4,-methylenedioxymethamphetamine (MDMA) has been recognised as a drug with therapeutic potential. Research on its clinical utility stopped when it entered the recreational drug scene but has slowly resurrected in the past decade. Currently there is enough evidence for MDMA to be removed from its Schedule 1 status of 'no medical use' and moved into Schedule 2 (alongside other misused but useful medicines such as heroin and amphetamine). Such a regulatory move would liberate…
29 Citations
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References
SHOWING 1-10 OF 19 REFERENCES
Could MDMA be useful in the treatment of post‐traumatic stress disorder?
- Psychology
- 2011
Dr Sessa discusses controversies and describes a UK‐based MDMA/PTSD currently in development, which she describes as an adjunct to post‐trauma psychological therapy.
Brain serotonin transporter binding in former users of MDMA ('ecstasy').
- Biology, MedicineThe British journal of psychiatry : the journal of mental science
- 2009
To the extent that [(11)C]DASB binding provides an index of the integrity of serotonin neurons, the findings suggest that MDMA use may not result in long-term damage to serotonin neurons when used recreationally in humans.
Effects of MDMA and Intranasal Oxytocin on Social and Emotional Processing
- Psychology, BiologyNeuropsychopharmacology
- 2014
The present findings provide only limited support for the idea that oxytocin produces the prosocial effects of MDMA, which increases euphoria and feelings of sociability.
Subjective reports of the effects of MDMA in a clinical setting.
- MedicineJournal of psychoactive drugs
- 1986
The psychological effects of MDMA were first relaboratory of Alexander Shulgin, Ph.D., who had colported in 1978 by Shulkin and Nichols and was no synthesis, and was synthesized in the actual or possible pregnancy.
MDMA effects consistent across laboratories
- Biology, PsychologyPsychopharmacology
- 2014
The subjective and physiological responses to the drug across three different laboratories and the influence of prior MDMA use indicate that the pharmacological effects of MDMA are robust and highly reproducible across settings.
A Window into the Intoxicated Mind? Speech as an Index of Psychoactive Drug Effects
- PsychologyNeuropsychopharmacology
- 2014
Abused drugs can profoundly alter mental states in ways that may motivate drug use. These effects are usually assessed with self-report, an approach that is vulnerable to biases. Analyzing speech…
A reconsideration and response to Parrott AC (2013) “Human psychobiology of MDMA or ‘Ecstasy’: an overview of 25 years of empirical research”
- PsychologyHuman psychopharmacology
- 2014
Though it critiques an attempt by other authors to characterize the risks of MDMA, the review fails to produce a competing model of risk assessment, and does not discuss potential benefits, which may deter researchers from further investigating an innovative treatment.
MDMA decreases the effects of simulated social rejection
- PsychologyPharmacology Biochemistry and Behavior
- 2014
The Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level–Dependent Resting State Functional Connectivity
- Biology, MedicineBiological Psychiatry
- 2015
MDMA assisted psychotherapy found to have a large effect for chronic post-traumatic stress disorder
- PsychologyJournal of psychopharmacology
- 2013
These subjects with resistant, chronic PTSD showed, on average, a substantial improvement in PTSD symptoms over the course of MDMA assisted psychotherapy, which is a potential solution to express the findings in terms of effect sizes using Cohen’s d.