Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo

  title={Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo},
  author={Sebastian J. Arnold and Elizabeth J. Robertson},
  journal={Nature Reviews Molecular Cell Biology},
Genetic studies have identified the key signalling pathways and developmentally regulated transcription factors that govern cell lineage allocation and axis patterning in the early mammalian embryo. Recent advances have uncovered details of the molecular circuits that tightly control cell growth and differentiation in the mammalian embryo from the blastocyst stage, through the establishment of initial anterior–posterior polarity, to gastrulation, when the germ cells are set aside and the three… 
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