Making Microtubules and Mitotic Spindles in Cells without Functional Centrosomes

@article{Mahoney2006MakingMA,
  title={Making Microtubules and Mitotic Spindles in Cells without Functional Centrosomes},
  author={Nicole M. Mahoney and Gohta Goshima and Adam Douglass and Ronald D. Vale},
  journal={Current Biology},
  year={2006},
  volume={16},
  pages={564-569}
}
Centrosomes are considered to be the major sites of microtubule nucleation in mitotic cells (reviewed in ), yet mitotic spindles can still form after laser ablation or disruption of centrosome function . Although kinetochores have been shown to nucleate microtubules, mechanisms for acentrosomal spindle formation remain unclear. Here, we performed live-cell microscopy of GFP-tubulin to examine spindle formation in Drosophila S2 cells after RNAi depletion of either gamma-tubulin, a microtubule… CONTINUE READING

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