Making Life or Death Choices with CBP

  title={Making Life or Death Choices with CBP},
  author={Elizabeth Mosby Adler},
  journal={Science's STKE},
  pages={tw132 - tw132}
  • E. Adler
  • Published 17 April 2007
  • Biology, Chemistry
  • Science's STKE
The transcriptional coactivator CBP (CREB-binding protein) can interact with p53, and thereby promote apoptosis, or with the functionally antagonistic transcription factor nuclear factor κB (NF-κB), and thereby promote cell proliferation. Huang et al. found that tumor necrosis factor-α (TNF-α) not only enhanced CBP association with the NF-κB p65 subunit (as previously shown) and CBP recruitment to NF-κB-responsive promoters but also decreased CBP binding to p53 and its association with p53…