Making, Exporting, and Modulating Wnts.

  title={Making, Exporting, and Modulating Wnts.},
  author={Paul F Langton and Satoshi Kakugawa and Jean-Paul Vincent},
  journal={Trends in cell biology},
  volume={26 10},
Wnt proteins activate a conserved signalling pathway that controls development and tissue homeostasis in all metazoans. The intensity of Wnt signalling must be tightly controlled to avoid diseases caused by excess or ectopic signalling. Over the years, many proteins dedicated to Wnt function have been identified, including Porcupine, which appends a palmitoleate moiety that is essential for signalling activity. This lipid inevitably affects subcellular trafficking and solubility, as well as… CONTINUE READING
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