Majority of differentially expressed genes are down-regulated during malignant transformation in a four-stage model.

@article{Danielsson2013MajorityOD,
  title={Majority of differentially expressed genes are down-regulated during malignant transformation in a four-stage model.},
  author={Frida Danielsson and Marie Skogs and Mikael Huss and Elton Rexhepaj and Gillian O'Hurley and Daniel Klevebring and Fredrik Pont{\'e}n and Annica K B Gad and Mathias Uhl{\'e}n and Emma Lundberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 17},
  pages={6853-8}
}
The transformation of normal cells to malignant, metastatic tumor cells is a multistep process caused by the sequential acquirement of genetic changes. To identify these changes, we compared the transcriptomes and levels and distribution of proteins in a four-stage cell model of isogenically matched normal, immortalized, transformed, and metastatic human cells, using deep transcriptome sequencing and immunofluorescence microscopy. The data show that ∼6% (n = 1,357) of the human protein-coding… CONTINUE READING
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